Fecha de publicación: -- Fuente: PubMed "honey" Tremor Other Hyperkinet Mov (N Y). 2026 Nov 3;16:62. doi: 10.5334/tohm.1279. eCollection 2026.ABSTRACTBACKGROUND: Tremor may recur after magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy, and the optimal target for deep brain stimulation (DBS) rescue remains uncertain.CASES: A 71-year-old man with recurrent essential tremor after ventral intermediate nucleus (Vim) MRgFUS underwent DBS along a Vim-posterior subthalamic area (PSA) trajectory. Microelectrode activity was attenuated in the lesioned thalamus; Vim test stimulation was ineffective, whereas PSA stimulation suppressed tremor. A 79-year-old man with recurrent tremor after staged bilateral MRgFUS underwent left DBS targeting the rubral wing.CONCLUSIONS: When the original thalamic target is anatomically or physiologically altered, targeting intact cerebellothalamic pathways provides a rational rescue strategy.HIGHLIGHTS: Deep brain stimulation can remain effective after failed focused ultrasound thalamotomy. These cases illustrate a lesion-informed, network-based strategy that preserves access to the cerebellothalamic network when prior lesioning has altered local anatomy or physiology.PMID:42997502 | PMC:PMC13741935 | DOI:10.5334/tohm.1279