Fecha de publicación: -- Fuente: PubMed "honey" J Agric Food Chem. 2026 Nov 4;74(43):33769-33779. doi: 10.1021/acs.jafc.6c11824.ABSTRACTEndocrine-disrupting bisphenol compounds (BPs) pose severe threats to human health, making the development of sensitive analytical methods urgently required. In this study, a novel cage-based porous organic polymer (Cage-R-TEB-POP) rich in predesigned molecular cavities and secondary amine groups was prepared via polymerization and reduction of organic cage monomer. The synergistic effects of host-guest recognition, hydrogen bond, and π-π stacking interactions endow Cage-R-TEB-POP with outstanding adsorption performance toward BPs. Subsequently, Cage-R-TEB-POP was employed as a solid-phase extraction adsorbent, combined with liquid chromatography-mass spectrometry, for the highly sensitive detection of trace BPs in honey, seaweed, and shrimp samples. The developed method exhibits detection limits as low as 0.20 ng g-1, with spiked recoveries ranging from 82.4% to 106% and relative standard deviations below 6.9%. This work establishes a robust approach for the analysis of trace-level BPs in food and proposes a promising strategy for the synthesis of cage-based novel materials.PMID:42980431 | DOI:10.1021/acs.jafc.6c11824