Fecha de publicación: -- Fuente: PubMed "hive" Ann Allergy Asthma Immunol. 2026 Nov 9:S1081-1206(26)01342-6. doi: 10.1016/j.anai.2026.11.001. Online ahead of print.ABSTRACTBACKGROUND: Sleep and mental health (MH) impacts have been understudied in chronic spontaneous urticaria (CSU); there is a lack of large, real-world cohort studies in the United States (US).OBJECTIVE: To describe the proportion of patients with claims for sleep and MH conditions, including health care resource utilization (HCRU), before (baseline) and after (follow-up) CSU diagnosis, and among patients with controlled vs uncontrolled CSU.METHODS: Adults (≥18 years) with CSU in the US HealthVerity claims database were included (January 2016-October 2023). Prespecified proxy events identified patients with uncontrolled CSU (any CSU-related inpatient [IP], emergency department [ED], or urgent care visit or any use of systemic corticosteroids, biologics, or immunosuppressants during follow-up). Claims for sleep-related conditions (insomnia, sleep-wake disorders), MH conditions (anxiety, chronic fatigue, depression, attention-deficit/hyperactivity disorder, somatic symptoms, and related disorders), sleep aids/antidepressants, and sleep and MH-related HCRU (outpatient, IP, and ED visits) were examined.RESULTS: Overall, 224,958 patients were included (mean follow-up: 2.4 years). The proportion of patients with claims for sleep-related conditions increased from baseline to follow-up (8.8% vs 15.4%), and for MH conditions (40.6% vs 56.3%). In total 113,932 patients (50.6%) experienced uncontrolled CSU; a higher proportion of patients with uncontrolled vs controlled disease had ≥1 claim for sleep-related (17.3% and 13.4%) and MH conditions (60.6% and 51.9%). Sleep and MH-related HCRU increased after CSU diagnosis and was greater among patients with uncontrolled vs controlled disease.CONCLUSION: Claims for sleep-related and MH conditions increased after CSU diagnosis, particularly among patients with uncontrolled disease, highlighting the need for more effective management.PMID:43003384 | DOI:10.1016/j.anai.2026.11.001