Fecha de publicación: -- Fuente: PubMed "hive" Clin Transl Allergy. 2026 Nov;16(11):e70220. doi: 10.1002/clt2.70220.ABSTRACTBACKGROUND: In chronic spontaneous urticaria (CSU), exacerbations are often associated with aggravating factors. However, the prevalence of patients having aggravating factors has been insufficiently studied. This mHealth study aimed to (i) estimate the prevalence of patient-reported perceived aggravating factors for CSU across 10 countries, and (ii) identify factors associated with such triggers.METHODS: We performed a cross-sectional analysis of data from users of the CRUSE mobile application. The study included patients aged 15-74 years with self-reported CSU. We assessed the frequency of reporting at least one of the following perceived aggravating factors: stress, food, exercise, low or high temperature, rubbing of the skin, infection, and medication. To correct for sample biases in age and sex distribution, we employed Multilevel Regression with Poststratification (MRP) models. In addition, we built logistic regression models to identify factors associated with perceived aggravating factor reporting.RESULTS: Of the 12,243 included participants, 62.1% reported at least one perceived aggravating factor. Stress (31.1%) and rubbing of the skin (23.1%) were the most common. After MRP, the frequency of reporting at least one perceived aggravating factor ranged between 39.6% (Japan) and 83.7% (Brazil). The reporting frequency was lower in Asian than in Western countries. Female sex was independently associated with higher odds of reporting most perceived aggravating factors, except exercise and food. Younger age and lower disease control were associated with higher aggravating factor reporting.CONCLUSIONS: Patient-reported perceived aggravating factors varied substantially across countries. Female sex, younger age, and poorer disease control were associated with increased reporting. Cross-country differences may reflect biological, healthcare-related, cultural, and psychosocial influences.PMID:43000211 | DOI:10.1002/clt2.70220