Fuente: PubMed "hive" Front Immunol. 2025 Nov 11;16:1668840. doi: 10.3389/fimmu.2025.1668840. eCollection 2025.ABSTRACTBACKGROUND: Immune-mediated dermatological conditions, including dermatitis, urticaria, alopecia areata, and psoriasis, are common skin diseases that contribute to substantial health loss, economic burden, and pain across individuals of all ages worldwide.METHODS: Using data from the Global Burden of Disease (GBD) 2021 study, we analyzed age-standardized incidence, prevalence rate, and disability-adjusted life years (DALYs) for global main four immune-related skin diseases-including dermatitis (atopic, contact, and seborrheic), urticaria, alopecia areata, and psoriasis from 1991 to 2021, with corresponding 95% uncertainty intervals (UIs), stratified by sex, age, geographical location, and sociodemographic index (SDI). We further projected incidence through 2035 using a Holt-damped model incorporating trend components but excluding seasonality.​RESULTS​: Dermatitis had the highest estimated age-standardized prevalence rate (ASPR: 5459.07 per 100,000; 95% UI: 5064.87-5875.73), followed by psoriasis (354.07; 95% UI: 342.42-364.08), urticaria (1094.59; 95% UI: 969.18-1240.42), and alopecia areata (42.89; 95% UI: 41.74-44.14). Immune-related dermatoses consistently showed higher age-standardized rates in females than males. The estimated annual percentage change (EAPC) revealed distinct temporal patterns: dermatitis (-0.155) and alopecia areata (-0.127) showed slight declines, whereas psoriasis exhibited an upward trend (0.24), and urticaria remained stable with a modest increase (0.01). Age distribution: Dermatitis/urticaria peaked in children, alopecia areata in adulthood, and psoriasis in middle age.CONCLUSIONS​: Immune-related skin diseases-including dermatitis, urticaria, alopecia areata, and psoriasis-are highly prevalent worldwide, with notable variations by age, sex, and region. Females are disproportionately affected. These trends underscore the need for targeted, sex- and region-specific public health interventions to optimize the allocation of healthcare.PMID:41306982 | PMC:PMC12644009 | DOI:10.3389/fimmu.2025.1668840