Fecha de publicación: 30/11/2021 Fuente: Wipo Tobacco Agriculture The invention discloses a quinoline alkaloid compound (I) as well as a preparation method and application thereof. The method comprises the following steps of: by taking cigar rootstocks as a raw material, extracting with high-concentration methanol, high-concentration acetone/water or high-concentration ethanol/water, merging extracting solutions, filtering, and concentrating under reduced pressure to obtain extract; packing the extract by using a silica gel dry method and carrying out silica gel column chromatography; carrying out gradient elution by using a chloroform-acetone solution; and further separating and purifying the 8: 2 part of the eluent by using high-pressure liquid chromatography to obtain the required quinoline alkaloid compound. The invention further discloses application of the compound, and activity tests show that the compound has a good bacteriostatic effect. The compound disclosed by the invention is novel in structure and has relatively good antibacterial activity. When the compound is used for cigarette tipping paper, the possibility of bacterium breeding and reproduction in the cigarette tipping paper can be eliminated or reduced.