Fecha de publicación: 27/07/2021 Fuente: Wipo Tobacco Agriculture The invention provides preparation of a nanocrystallization prodigiosin preparation and application of the nanocrystallization prodigiosin preparation in prevention and treatment of viral diseases of vegetable economic crops, belongs to the technical field of application of microbial secondary metabolites, and can solve the problem of the nanocrystallization prodigiosin preparation in prevention and treatment of the viral diseases (PVY, TMV, CMV and TSWV) of main economic crops. The preparation is prepared from prodigiosin and a chitosan nano-material, the prodigiosin can significantly improve the ubiquitination level of plant host heat shock protein (HSP70), promote ubiquitination degradation of the host HSP70 protein, degrade or inhibit expression of the HSP70 protein, activate natural immunocompetence of host plants, and achieve the inhibition effect on common RNA viruses. The nanocrystallization prodigiosin preparation provided by the invention is used for preventing and treating virus diseases of main economic crops, so that the stability of prodigiosin is stronger, the effect is more durable, a good virus disease prevention and treatment effect can be achieved, and the nanocrystallization prodigiosin preparation has a good application prospect in the field of prevention and treatment of multiple viruses of the economic crops.