Fuente: WIPO "tobacco agriculture" The present invention relates to gene isolation and plant improvement, particularly to spotted wilt disease resistance gene RTSW from tobacco and use thereof. Provided are nucleic acid molecules for conferring or enhancing resistance to orthotospoviruses to a plant, and expression cassettes, vectors, host cells, plants and seeds comprising the nucleic acid molecules. The nucleic acid molecules encode RTSW gene products or variants thereof. Additionally provided are methods for conferring or enhancing resistance to orthotospoviruses to a plant, the method comprising introducing the nucleic acid molecules into plant cells.