Fuente: WIPO "tobacco agriculture" The invention discloses a sesquiterpenoid compound and a preparation method and application thereof. The sesquiterpenoid compound is separated from flue-cured tobacco leaves, is named as 6-hydroxymethyl-4-isopropyl-7-methoxy-1-naphthyl methyl formate, a molecular formula of the sesquiterpenoid compound is C17H20O4, and a structural formula is shown in the description. The preparation method of the sesquiterpenoid compound comprises the steps that the flue-cured tobacco leaves are used as a raw material, and extract extraction, silica gel column chromatography and high pressure liquid chromatography separation are performed to obtain the compound. An activity test proves that the sesquiterpenoid compound has a good bacteriostatic effect. The sesquiterpenoid compound is novel in structure and has good antibacterial activity. The compound is used for cigarette tipping paper, can eliminate or reduce the possibility of bacterial breeding and reproduction in the cigarette tipping paper.