Fecha de publicación: -- Fuente: WIPO "tomato" The present technology provides polypeptides that binds to PD-1. The present technology also provides nucleic acids, vectors and compositions. Also provided are multispecific binding proteins (e.g., bispecific binding proteins) that targeting a TNF receptor superfamily (TNFRSF) receptor (e.g., GITR) and an immune checkpoint protein (e.g., PD-1).