CUCUMOVIRUS CHIMERIC CAPSID PROTEIN

Fecha de publicación: --
Fuente: WIPO "tomato"
There is described a chimeric protein comprising a heterologous peptide of interest inserted 5 into the amino acid sequence of a capsid protein of a cucumovirus having an icosahedral capsid, such as Tomato Aspermy Virus (TASV) capsid protein, wherein the insertion site is at a site which avoids disruption to the capsid protein, for example between the first and second beta sheets of the TASV capsid protein. The heterologous peptide of interest can include an epitope which is available for binding by a separate binding partner, for example 0 an antibody or a cell receptor or other specific binding partner. One example is the binding domain of Im7.