Fuente: PubMed "olive oil" NPJ Sci Food. 2026 May 30. doi: 10.1038/s41538-026-00910-8. Online ahead of print.ABSTRACTHydroxytyrosol (HT), the most bioactive polyphenol in virgin olive oil, has been shown to have cardiometabolic benefits in obese rats, but the underlying mechanism has not been fully elucidated. The aim of this study was to explore the potential driving mechanism in the initiation node of obesity-induced myocardial fibrosis through in vivo and in vitro experiments, and the role of HT in obesity-induced myocardial fibrosis was investigated based on the above mechanisms. The results demonstrated that HT reduced cardiomyocyte oxidative stress and ultimately ameliorated myocardial injury and fibrosis in obese mice by inhibiting NLRP3 inflammasome-dependent pyroptosis, which in turn downregulated the deubiquitinating enzyme cylindromatosis (CYLD), thereby reducing NADPH oxidase (NOX)4 deubiquitination and promoting its degradation.PMID:42225718 | DOI:10.1038/s41538-026-00910-8