Fecha de publicación: -- Fuente: PubMed "microbial biotechnology" Fitoterapia. 2026 Nov 9:107555. doi: 10.1016/j.fitote.2026.107555. Online ahead of print.ABSTRACTStreptococcus agalactiae (Group B Streptococcus, GBS) is still a major cause of infections in newborns and poses risks due to maternal colonization. It also has economic impacts on livestock and aquaculture. The increasing incidence of resistance to common antibiotics and the lack of a licensed, effective vaccine highlight the urgent need for new ways to prevent and treat these infections. Plant-derived phytochemicals have attracted considerable attention for their wide-ranging antibacterial properties, multiple mechanisms of action, and lower chances of causing resistance. This review summarizes phytochemicals reported over the past decade that inhibit the growth, virulence, and biofilm formation of S. agalactiae. Compounds such as phenylpropanoids, flavonoids, terpenoids, alkaloids, saponins, and essential oils (EOs) show antibacterial, antibiofilm, and anti-virulence effects. They act through several mechanisms: disruption of the cell membrane, inhibition of sortase A and pili production, reduced expression of virulence genes, and modulation of host immune responses. Furthermore, many phytochemicals have additive or synergistic effects when used with traditional antibiotics, helping to restore sensitivity in antibiotic-resistant strains. Overall, the available evidence highlights eugenol as a promising candidate due to its strong effects against bacteria and biofilms, effectiveness against resistant strains, and significant synergistic potential. Other compounds, including cinnamon oil, baicalin, rutin, and certain EOs, also show promise as alternatives or supplements for managing S. agalactiae infections in clinical, veterinary, and aquaculture settings.PMID:43003145 | DOI:10.1016/j.fitote.2026.107555