Fecha de publicación: -- Fuente: PubMed "plant biotechnology" J Mater Chem B. 2026 Nov 9. doi: 10.1039/d6tb01188h. Online ahead of print.ABSTRACTOxidative stress is a key pathological factor of myocardial injury, contributing to cardiomyocyte dysfunction and irreversible tissue damage. Current cardiac healthcare systems face difficulties to restore redox balance during oxidative stress condition. Therefore, development of nanomedicne system capable of regulating redox balance represents a promising strategy for myocardial protection. In this study we design a redox-active cerium based nanomedicine by the integration with metal organic framework and stabilizing the system using plant derived extract to form the Ce@MOF@PE hybrid nanoassembly. In this study we conducted complete physicochemical characterization of the Ce@MOF@PE nanomedicine to prove that they had successfully modified its properties while maintaining its original structural elements. The mixed valence states of Ce3+/Ce4+ demonstrated their capability to show analytical redox catalytic functions. Physicochemical characterization confirmed stable nanoassembly formation and the presence of mixed cerium valence states enabling continuous redox cycling. Adrenaline-induced myocardial stress caused severe biochemical disruption, manifesting as 60-80% reductions in Superoxide dismutase (SOD), Catalase (CAT), Peroxidase (POD), and Reduced glutathione (GSH), with a 150-200% increase in (Reactive oxygen species (ROS) and Thiobarbituric acid reactive substances (TBARS). Ce@MOF@PE nanomedieine showed the maximum restoration of antioxidants, recovering SOD by 92%, CAT by 88%, POD by 95%, and GSH by 90%, and simultaneously eliminating ROS and TBARS by approximately 70% and 65% respectively compared to the stressed group. Stress-induced elevation of serum cardiac injury markers (Creatine kinase (CK), Creatine kinase-MB (CK-MB), Cardiac troponin I cTnI, Cardiac troponin T cTnT) by 120-180% was mitigated by 75-90% after Ce@MOF@PE treatment. These findings demonstrates how materials can establish redox regulation systems which reduce oxidative damage to the heart muscle while proving that cerium-based nanomedicine functions as a potential therapeutic treatment for cardiovascular diseases.PMID:43001884 | DOI:10.1039/d6tb01188h