Fuente: PubMed "medicinal and aromatic plants" Org Lett. 2026 Feb 13;28(6):2062-2068. doi: 10.1021/acs.orglett.5c05350. Epub 2026 Jan 30.ABSTRACTHyperesternoids A-K (1-11, respectively), 11 unique esterified seco-PPAPs (seco-polycyclic polyprenylated acylphloroglucinols) with three types of scaffold systems, 5/6 bicyclic (1-3), 5/7/6 tricyclic (4-6), and 5/6/6 tricyclic (7-11), were isolated from two plants of the Hypericum genus. Notably, crystalline mate and chemical transformation methods provided several practical strategies for the elucidation of seco-PPAPs with complex and variable structures. Biologically, the PPARα agonistic activities of all isolates were evaluated via the dual-luciferase reporter assay, and their lipid-lowering effects were studied.PMID:41615768 | DOI:10.1021/acs.orglett.5c05350