Fuente: PubMed "medicinal and aromatic plants" In Silico Pharmacol. 2026 Mar 17;14(1):86. doi: 10.1007/s40203-025-00483-6. eCollection 2026.ABSTRACTGymnema sylvestre, a medicinal plant renowned for its anti-diabetic properties, has long been used in traditional medicine. Its active compound, gymnemic acid, is known to regulate glucose metabolism and inhibit sugar absorption, making it a promising compound for Diabetes mellitus management. This study investigates the molecular interactions between gymnemic acid and five proteins critical to glucose regulation, circadian rhythm, immune response, and insulin signaling. Gene enrichment analysis was performed using the STRING database to examine the functional connections between the genes associated with these proteins, highlighting their involvement in diabetes mellitus. Molecular docking studies evaluated gymnemic acid's binding affinity to these proteins. The results showed strong binding interactions, with the highest binding energy of - 9.5 kcal/mol found for gymnemic acid with INS (PDB ID: 2WBY). Other significant interactions were identified with MTNR1B (PDB ID: 6ME6), FTO (PDB ID: 7CKK), GCK (PDB ID: 4BB9), and CTLA4 (PDB ID: 7CIO). The MDS results revealed that gymnemic acid formed stable complexes with most target proteins, indicated by low RMSD and RMSF values, compact Rg, and reduced SASA profiles. Consistent hydrogen bonding further supported stable binding. These findings affirm gymnemic acid's potential to modulate these proteins, supporting its role in glucose regulation, insulin sensitivity, and immune responses, offering a novel therapeutic approach for diabetes and metabolic disorders. Additionally, ADME/T profiling from published data suggests that gymnemic acid exhibits favorable pharmacokinetic and safety properties, making it an optimal candidate for further in vitro and in vivo investigations.SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40203-025-00483-6.PMID:41858338 | PMC:PMC12996508 | DOI:10.1007/s40203-025-00483-6