Artemiannua A, new sesquiterpenoid from the aerial part of artemisia annua with anti-inflammatory activity

Fuente: PubMed "medicinal and aromatic plants"
Nat Prod Res. 2026 Apr 16:1-5. doi: 10.1080/14786419.2026.2658145. Online ahead of print.ABSTRACTArtemiannua A (1), a new sesquiterpenoid derivative, and a new natural compound (artemiannua B, 2), along with six known compounds (3-8), were isolated from Artemisia annua (sweet wormwood). The structures of the new compounds were elucidated by 1D/2D NMR, ECD, and HR-ESI-MS experiments. The anti-inflammatory activities of compounds 1-8 were evaluated using the Griess assay. In LPS-induced RAW264.7 macrophages, compounds 1, 2, 5, and 6 markedly reduced NO generation, suggesting possible anti-inflammatory properties. Furthermore, the MTT technique was used to evaluate the hepatoprotective properties of compounds 1-8 against liver damage caused by acetaminophen.PMID:41989199 | DOI:10.1080/14786419.2026.2658145