Fuente: PubMed "essential oil" J Ethnopharmacol. 2026 Jul 9;372:122178. doi: 10.1016/j.jep.2026.122178. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Jurema constitutes an important ethnobotanical complex in Brazil, encompassing medicinal plants and healing practices rooted in Indigenous traditions and re-elaborated within Afro-Brazilian contexts. Mimosa gemmulata is included in the Jurema repertoire and is used in Brazilian traditional medicine to treat pain and inflammation.AIM OF THE STUDY: To investigate the antinociceptive and anti-inflammatory properties of M. gemmulata essential oil (MGEO), and its mechanism of action.MATERIALS AND METHODS: The anti-inflammatory potential of MGEO was evaluated using stimulated RAW 264.7 macrophage. MGEO was chemically characterized by GC/MS. The pharmacological properties of MGEO were characterized in male Swiss mice in the formalin, tail flick, and hot plate tests; and complete Freund's adjuvant (CFA)-induced paw inflammation. The mechanism of action was investigated using IL-10 knockout (IL-10-/-) mice and by quantifying local cytokine levels by ELISA.RESULTS: MGEO reduced NO production in stimulated macrophages. MGEO is predominantly composed of mono- and sesquiterpenes. Oral administration of MGEO (100-200 mg/kg) inhibited both phases of the formalin test (p < 0.05), induced antinociception in the hot plate test, with no effect in the tail flick test, and did not impair motor performance. MGEO reduced paw edema and induced antinociception in the CFA model in wild-type mice; however, these effects were abolished in IL-10-/- mice. MGEO reduced local levels of pro-inflammatory cytokines IL-1β and TNF-α, while markedly increasing anti-inflammatory cytokine IL-10.CONCLUSION: MGEO exerts antinociception and anti-inflammatory effects mediated by IL-10, involving a shift in the local cytokine milieu toward an anti-inflammatory profile.PMID:42425375 | DOI:10.1016/j.jep.2026.122178