Fuente: PubMed "essential oil" Front Pharmacol. 2026 Jun 2;17:1688998. doi: 10.3389/fphar.2026.1688998. eCollection 2026.ABSTRACTINTRODUCTION: Arboviruses represent a serious problem affecting half of the world's population, according to the World Health Organization. Natural products are an option for combating this vector.METHOD: The essential oil (EO) of E. uniflora was extracted by hydrodistillation, while the isolation of the main constituent of the oil (curzerene) was also performed by countercurrent chromatography, with a purity greater than 97%. Larvicidal tests were performed by exposing L4 stage larvae to the EO and the major constituent. The oviposition deterrent effect and the electroantennographic response of Ae. aegypti females were also investigated. Histological sections were performed to assess the damage caused by the oil, and docking studies were performed with the major constituent.RESULTS: Bioassays demonstrated promising larvicidal activity of the essential oil (LC50 = 52.20 ppm) and curzerene (LC50 = 55.70 ppm), as well as a promising oviposition deterrent action, since the oil reduced egg laying by more than 74% at 50 ppm and 65% at 5 ppm, and curzerene reduced egg laying by 65% at 56 ppm. Gas chromatography and electroantennography revealed depolarization of Ae. aegypti antennae by the main constituent of the essential oil (curzerene), which is consistent with the oviposition deterrent activity. Molecular docking studies and histological analyses suggest alterations in the digestive membrane and enzymes during exposure to the essential oil.CONCLUSION: Therefore, the essential oil of Eugenia uniflora and its main constituent (curzerene) may be options for vector control programs.PMID:42311415 | PMC:PMC13270230 | DOI:10.3389/fphar.2026.1688998