Fuente: PubMed "essential oil" Front Microbiol. 2026 Jan 29;16:1712904. doi: 10.3389/fmicb.2025.1712904. eCollection 2025.ABSTRACTINTRODUCTION: This study investigated the dose-response efficacy of dietary oregano essential oil (OEO) in mitigating severe heat stress (THI ≈ 86) in beef cattle.METHODS: Thirty-six Pinan bulls were fed a basal diet alone (control) or supplemented with 7 (L-OEO) or 14 g/d (H-OEO) of OEO for 60 days.RESULTS: The low-dose OEO (7 g/d) significantly improved hepatic function (reduced ALT, AST; increased ALB, TP), enhanced immune (increased IgA, IgM) and antioxidant status (decreased MDA, increased SOD, CAT), and increased the ruminal abundance of Bacteroidota and Prevotella, which correlated negatively with acyl-glycine metabolites. In contrast, the high dose (14 g/d) only increased GSH-Px and T4, resulted in higher MDA than L-OEO, and did not significantly affect the rumen microbiota.CONCLUSION: Supplementation with 7 g/d OEO optimally improved overall health and metabolic function in heat-stressed bulls, whereas a 14 g/d dose offered no additional benefits.PMID:41695142 | PMC:PMC12894248 | DOI:10.3389/fmicb.2025.1712904