A novel hybrid non-alcoholic solvent solution and fabric for antimicrobial applications provides a non-toxic, economical, biodegradable, anti-microbial solution, that not only inhibits the growth but also kills microbial pathogens. In certain embodiments, the hybrid solvent composition includes extracts of curcumin, Syzygium aromaticum, Azadirachta indica, Trachyspermum Ammi, Cinnamomum Camphora, Cinnamomum Verum, and Elettaria Cardamomum.