The present invention relates to a novel homeopathic composition useful for treating pain and/or inflammation comprising tinctures and/or diluted extracts. More particularly, there is provided a composition which contains a synergistic combination of extracts from Terminalia arjuna, Sticta pulmonaria, Colchicum autumnale, Gelsemium sempervirens, Ledum palustre and Cissus quadrangularis. The present invention also provides a method of preparation of the homeopathic drug composition as topical preparation, preferably as topical spray composition. Cissus quadrangularis extraction is also a novel process used in the composition where in cold extraction is applied for Cissus quadrangularis.