Fuente: WIPO "essential oil or extracts" Provided herein are compositions comprising therapeutically effective amounts of at least one cannabinoid and of punicalagin, as essentially pure isolates or synthetic or as components of essential oils or plant extracts or combinations thereof. The combination compositions comprising punicalagin and cannabidiol (CBD) exhibit a strong synergistic effect in the reduction of the local aorta pro-inflammatory IL-6 cytokine levels. This result demonstrates the potential superior and synergistic therapeutic efficacy that can be achieved by using these active agents as a combined atherosclerosis therapy as compared to each of them separately. The pharmaceutical compositions of this invention are useful for the treatment of inflammation in atherosclerotic plaques, thus rendering them less vulnerable to erupt and clog small blood vessels in the heart or brain, atherosclerosis or blood vessel calcification and reducing Reactive Oxygen Species (ROS) presence and reactive oxidative stress in atherosclerotic lesions, thus preventing further damage to vessel tissue and accumulation of debris, calcium, inflammatory agents and cells in lesions.