ANTIFUNGAL COMPOSITION PREPARED FROM ESSENTIAL OIL OF LEAVES OF CITRUS PSEUDOLIMON AND BIOAVAILABILITY ENHANCER OF ANTIFUNGAL ANTIBIOTICS

Fuente: WIPO "essential oil or extracts"
This invention relates to developing potent antifungal formulations based on essential oil of leaves of Citrus pseudolimon. The invention also provides a cheaper and sustainable source for the development of antifungal therapeutics from the leaves of Citrus pseudolimon. The medicinal plants offer a wealth of phytocompounds, including essential oils (EOs), which can be explored for antifungal activities. This study provides a sustainable and cheap source of essential oil from leaves of Citrus pseudolimon, that showed antifungal activity against Candida strains. The essential oil extracted from the leaves of Citrus pseudolimon also enhanced the bioavailability (synergistic effect) of Fluconazole and Amphotericin B by 5 to 8 folds respectively. Essential oils of Citrus pseudolimonshows synergistic effects with Amphotericin B and Fluconazole against S. cerevisiae(H1086),Candida albicans(ATCC90028) and Candida albicans(MTCC277).