A SYNERGISTIC ANTI-FUNGAL COMPOSITION OF ESSENTIAL OIL EXTRACTED FROM NEEDLES OF JUNIPERUS COMMUNIS WITH ANTIBIOTICS FOR TREATING CANDIDIASIS

Fuente: WIPO "essential oil or extracts"
This invention relates to a synergistic anti-fungal composition of essential oil extracted from needles of juniperus communis with antibiotics for treating candidiasis. Essential oils and their active phytocompounds can be explored as a resource to enhance or modify the potency of antibiotics, which have lost efficacy due to emergence of drug resistance in fungal pathogen. The present invention discloses that the, essential oil extracted from the leaves (needles) of J. communis showed synergistic effect when combined with the antibiotics Amphotericin B and Fluconazole. Essential oil reduced the dosage of the antibiotics by ~ 10- 100 folds. The essential oil alone or essential oil in combination with antibiotics can be used directly to develop improved topical or oral formulation for treating fungal infections in humans and animals.