Fuente: WIPO "essential oil or extracts" The invention relates to field of antifungal bio-enhancer properties of the phytocompounds present in essential oil of Acorus calamus. Phytocompounds present in essential oils can be explored as a resource to enhance or modify the potency of antibiotics which have lost efficacy due to emergence of drug resistance in fungal pathogen. The present invention discloses that the, essential 10 oil extracted from the leaves of Acorus calamus showed synergistic effect when combined with as amphotericin B and fluconazole. Essential oil reduced the dosage of the antibiotics. The essential oil alone or essential oil in combination with antibiotics can be use directly to develop improved topical or oral formulation for treating fungal infections in humans and animals. 15