Fecha de publicación:
31/10/2024
Fuente: Biomolecules - Revista científica (MDPI)
Biomolecules, Vol. 14, Pages 1393: The Dual Burden: Exploring Cardiovascular Complications in Chronic Kidney Disease
Biomolecules doi: 10.3390/biom14111393
Authors:
Alfredo Caturano
Raffaele Galiero
Maria Rocco
Giuseppina Tagliaferri
Alessia Piacevole
Davide Nilo
Giovanni Di Lorenzo
Celestino Sardu
Vincenzo Russo
Erica Vetrano
Marcellino Monda
Raffaele Marfella
Luca Rinaldi
Ferdinando Carlo Sasso
Chronic kidney disease (CKD) represents a significant global health challenge, affecting millions of individuals and leading to substantial morbidity and mortality. This review aims to explore the epidemiology, cardiovascular complications, and management strategies associated with CKD, emphasizing the importance of preventing cardiovascular disease and early intervention. CKD is primarily driven by conditions such as diabetes mellitus, hypertension, and cardiovascular diseases, which often coexist and exacerbate renal impairment. Effective management requires a multifaceted approach, including lifestyle modifications, pharmacological interventions, and regular monitoring. Dietary changes, such as sodium restriction and a controlled intake of phosphorus and potassium, play a vital role in preserving renal function. Pharmacological therapies, particularly angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and emerging agents like SGLT2 inhibitors, have shown efficacy in slowing disease progression and improving patient outcomes. Furthermore, patients undergoing dialysis face increased cardiovascular risk, necessitating comprehensive management strategies to address both renal and cardiac health. As the landscape of CKD treatment evolves, ongoing research into novel therapeutic options and personalized medical approaches are essential. This review underscores the urgent need for awareness, education, and effective preventive measures to mitigate the burden of CKD and enhance the quality of life for affected individuals.
