Fecha de publicación: -- Fuente: PubMed "honey" Inflammopharmacology. 2026 Sep 22. doi: 10.1007/s10787-026-02395-z. Online ahead of print.ABSTRACTHoney has been traditionally used for the management of respiratory disorders, including asthma, yet its mechanistic relevance in allergic airway inflammation remains insufficiently clarified. The present study investigated the chemical composition, antioxidant capacity, and anti-inflammatory effects of two Moroccan monofloral honeys, Ziziphus lotus (L.) Lam and Eryngium campestre L., in a rat model of ovalbumin (OVA)-induced allergic asthma, and explored potential molecular interactions of major phenolic constituents with key signaling proteins involved in disease pathophysiology. Physicochemical properties were determined according to standard methods. Total phenolic and flavonoid compounds (TPC and TFC) were quantified using colorimetric assays, while ascorbic acid content was determined by titrimetric analysis. Phenolic profiles were characterized by high-performance liquid chromatography, and antioxidant activity was assessed using radical-scavenging and total antioxidant capacity assays. In vivo effects were evaluated through hematological analysis, immunoglobulin E (IgE) quantification, bronchoalveolar lavage cellularity, and histopathological examination. Both honeys met international quality standards and exhibited distinct phenolic signatures. Eryngium campestre L. honey showed higher phenolic and flavonoid contents and stronger antioxidant activity compared with Ziziphus lotus (L.) Lam honey. OVA sensitization induced a marked leukocyte infiltration and elevated the IgE levels, whereas honey supplementation reduced significantly inflammatory cell counts and IgE concentrations and preserved lung architecture. Molecular docking indicated the favorable interactions of quercetin and kaempferol with spleen tyrosine kinase (SYK), mitogen-activated protein kinase 3 (MAPK3), and signal transducer and activator of transcription 6 (STAT6). These findings suggest that Moroccan monofloral honeys exert antioxidant and immunomodulatory effects and may attenuate allergic airway inflammation through the modulation of the key inflammatory signaling pathways.PMID:42771299 | DOI:10.1007/s10787-026-02395-z