Fuente: PubMed "essential oil" J Microencapsul. 2026 Jun 1:1-17. doi: 10.1080/02652048.2026.2667728. Online ahead of print.ABSTRACTThe study aimed to evaluate the in vitro activities of pink lotus essential oil (PLEO) and develop a PLEO-loaded hydrogel formulation to promote wound healing. The antibacterial, anti-inflammatory, and cell proliferation and migration-promoting activities of PLEO were determined. PLEO was microencapsulated by β-cyclodextrin (β-CD) and incorporated into a hydrogel matrix. The in vivo wound healing efficacy and underlying mechanisms of the hydrogel were examined in a mouse model. PLEO inhibited Staphylococcus aureus, Pseudomonas aeruginosa, and Staphylococcus epidermidis, suppressed LPS-induced secretion of inflammatory factors, while promoting proliferation and migration of HUVECs and HSFs cells. The prepared hydrogels loading PLEO microcapsules showed a good physicochemical properties,andmarkedly accelerated wound healing in mice and upregulated the expression of type Icollagen, α-SMA and VEGF, PI3K, p-Akt, and p-eNOS inwound tissues.The hydrogels containing PLEO microcapsules accelerates wound healing through activation of the PI3K/Akt/eNOS signaling pathway.PMID:42224647 | DOI:10.1080/02652048.2026.2667728