Comité Oleícola Internacional Lugar: Sin categoría The Mediterranean diet has the most consistent associations with lower risk of chronic diseases and mortality. Adding more evidence in that direction, a large-scale prospective epidemiological cohort study of 25,315 women from the US with a 25-year follow-up showed that higher adherence to the Mediterranean diet was associated with approximately one fifth relative risk reduction in all-cause mortality, CVD and non-CVD mortality. In addition, the authors quantified the contribution of traditional and novel biological biomarkers to this association. The analysis showed that the association between the Mediterranean diet and all-cause mortality risk reduction was partially explained by potential mediation through metabolites (e.g. alanine), inflammatory biomarkers, triglyceride rich lipoprotein measures, adiposity and insulin resistance markers.Fecha de publicación: 27/11/2023 Fuente:
As demonstrated in the previous study, adiposity could be a potential mediator in the association between the Mediterranean diet and reduced mortality. Therefore, it would be most interesting to demonstrate the effect of a Mediterranean diet intervention on weight management in the long term. In this sense, the PREDIMED-Plus trial has assessed the effect of a multifactorial intervention with an energy-reduced Mediterranean diet, physical activity promotion, and behavioral support, on changes in body composition components after 3 years. Compared to the control group (only Mediterranean diet) individuals in the intervention group showed greater reductions in the percentage of total fat and visceral fat and a greater increase in the percentage of total lean mass at 1 year and 3 years of the intervention.
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