Fecha de publicación: 16/11/2021 Fuente: WIPO "royal jelly" The invention discloses a royal jelly zymolyte which is obtained by performing enzymolysis on royal jelly through protease M-P001. The protease M-P001 is derived from mycobacterium tuberculosis, and the amino acid sequence of the protease M-P001 is as shown in SEQ ID NO. 1 (sequence identifier number 1). The enzymolysis conditions are as follows: protease M-P001 is used for enzymolysis of the royal jelly aqueous solution, and the royal jelly concentration in the royal jelly aqueous solution is 5-20%; protease M-P001 is added according to the addition amount of 1500-2500U/g (based on royal jelly raw materials), the pH is 6.0-8.0, and enzymolysis is carried out for 20-25 hours at the temperature of 33-36 DEG C; the royal jelly zymolyte can remarkably improve the mononuclear-macrophage clearance capacity of mice and improve the NK cell activity of the mice, has the effect of improving the immunity activity, can be used as a raw material for preparing health care products, drugs or food with the effect of improving the immunity activity, and can remarkably improve the product value of royal jelly.