Fecha de publicación: 09/09/2021 Fuente: WIPO "royal jelly" The invention discloses a Panax quiquefolium and royal jelly double-layer buccal tablet and a preparation method thereof. The method adopts a single factor combined with an orthogonal test method, takes initial particle size, feeding amount, crushing time and temperature as influencing factors, and takes the average particle size of Panax quiquefolium ultra-fine powder as an index to optimize the superfine crushing process of Panax quiquefolium. The formulation process of Panax quiquefolium ultra-fine powder buccal tablets was optimized by single factor combined with response surface methodology, with flavoring agent, essence, disintegrating agent and lubricant as influencing factors and sensory comprehensive score as index. At last, a preparation method for preparing Panax quiquefolium royal jelly double-layer buccal tablet was established. The double-layer buccal tablet prepared by this preparation method can not only keep the original flavor and active ingredients of Panax quiquefolium and royal jelly, but also release them quickly in the oral cavity, and has the effects of relieving physical fatigue and enhancing immunity. Moreover, it is rich in taste, small in shape, convenient to carry and easy to absorb by human body.