ODORANT RECEPTOR CO-RECEPTOR

Fecha de publicación: 07/08/2019
Fuente: WIPO "apis mellifera"
Provided is an insect odorant receptor co-receptor that exhibits excellent detection sensitivity to an odorous substance when bound to an odorant receptor to form an odorant receptor complex. The odorant receptor co-receptor of the invention includes the following first amino acid sequence and the following second amino acid sequence subsequently to the farthest carboxyl-terminal amino acid residue of the first amino acid sequence: (1) a first amino acid sequence, which is a partial amino acid sequence of an odorant receptor co-receptor of a first insect or a variant of the co-receptor, the partial amino acid sequence being an amino acid sequence that is contiguous from the amino-terminus of the odorant receptor co-receptor of the first insect or a variant of the co-receptor to any one amino acid residue positioned in the range of twenty amino acid residues before and after the farthest carboxyl -terminal amino acid residue of the fourth transmembrane domain; and (2) a second amino acid sequence, which is a partial amino acid sequence of an odorant receptor co-receptor of a second insect of a variety different from the first insect or a variant of the co-receptor, the partial amino acid sequence being an amino acid sequence that is contiguous from an amino acid residue at a position that is on position one carboxyl-terminal to a position corresponding, in an alignment analysis of the amino acid sequence of the first insect odorant receptor co-receptor or the variant thereof and the amino acid sequence of the second insect odorant receptor co-receptor or the variant thereof, to the farthest carboxyl-terminal amino acid residue of the first amino acid sequence in the odorant receptor co-receptor of the second insect or a variant of the co-receptor, to the carboxyl-terminus of the odorant receptor co-receptor of the second insect or a variant of the co-receptor.