PROXIMITY INTERACTION ANALYSIS

Fecha de publicación: 12/03/2020
Fuente: WIPO "miel"
The present disclosure relates to methods for assessing identity and spatial relationship between a polypeptide and a moiety in a sample. In some embodiments, both the polypeptide and the moiety are parts of a larger polypeptide, and the present methods can be used assess identity and spatial relationship between the polypeptide and the moiety in the same polypeptide or protein. In other embodiments, the polypeptide and the moiety belong to different molecules, and the present methods can be used assess identity and spatial relationship between the polypeptide and the moiety different molecules, e.g., in a protein-protein complex, a protein- DNA complex or a protein-KNA complex.