Fecha de publicación: 18/11/2024 Fuente: Molecules - Revista científica (MDPI) Molecules, Vol. 29, Pages 5440: Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review
Molecules doi: 10.3390/molecules29225440
Authors:
Wen Hou
Lejun Huang
Jinyang Wang
Walter Luyten
Jia Lai
Zhinuo Zhou
Sishuang Kang
Ping Dai
Yanzhu Wang
Hao Huang
Jinxia Lan

Pigeon pea (Cajanus cajan (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties. Cajaninstilbene acid (CSA), a stilbene compound derived from pigeon pea leaves, has been extensively investigated since the 1980s. A thorough understanding of CSA’s mechanisms of action and its therapeutic effects on various diseases is crucial for developing novel therapeutic approaches. This paper presents an overview of recent research advancements concerning the biological activities and mechanisms of CSA and its derivatives up to February 2024. The review encompasses discussions on the in vivo metabolism of CSA and its derivatives, including antipathogenic micro-organisms activity, anti-tumor activity, systematic and organ protection activity (such as bone protection, cardiovascular protection, neuroprotection), anti-inflammatory activity, antioxidant activity, immune regulation as well as action mechanism of CSA and its derivatives. The most studied activities are antipathogenic micro-organisms activities. Additionally, the structure–activity relationships of CSA and its derivatives as well as the total synthesis of CSA are explored, highlighting the potential for developing new pharmaceutical agents. This review aims to provide a foundation for future clinical applications of CSA and its derivatives.