Fecha de publicación: 21/11/2024 Fuente: Journal of applied polymer Lugar: RESEARCH ARTICLE Microwave-assisted–based metformin hydrogel is developed and evaluated.

Microwave-assisted hydrogel played major role in wound healing effect of drug.

Microwave-assisted hydrogel containing locust bean gum and metformin 2:1.5 was the best optimized formulation.


ABSTRACT
The goal of this study was to fabricate gelatin cross-linked Locust bean gum (LBG)/guar gum–based hydrogels with microwave assistance for diabetic wound healing applications and evaluate it for physicochemical properties. In the last few years, microwave irradiation has gained acceptance as a reliable technique for quickening and streamlining chemically modified reactions. In order to achieve this, metformin-loaded LBG and guar gum–based hydrogel were formulated employing microwave radiation. Moreover, the microwave-assisted–based metformin hydrogel are microwave-assisted reaction sudden increase in temperature may led to distortion of molecules, very vigorous and which may be hazardous, but environmental sustainability and friendly chemistry concepts are supported by microwave irradiation. The optimized formulation (F3) showed significantly improved physicochemical properties, with a swelling capacity of 480.4% ± 2.5%. The results indicate an appropriate duration for adequate drugs diffusion and nutrition exchange. Controlled disintegrate and sustained release of embedded drug molecules from F3 may have an impact on antibacterial activity. The study indicated that microwave-assisted polymer blend hydrogels had adequately improved physical qualities, making them a promising candidate for improving diabetic wound healing and hastening skin tissue regeneration.