Fecha de publicación: 15/11/2024 Fuente: Cellulose (Springer) Abstract
In this study, TEMPO (2,2,6,6 tetra-methyl-piperidine-N-oxyl) oxidized nanofibrillated celluloses (CNFs; CNF1 having a higher amount of carboxyl fraction; 1.0613 mmol/g, CNF2 having a lower degree of carboxyl fraction; 0.5543 mmol/g) with different amounts of carboxyl and aldehyde fractions were prepared as the main aerogel matrix, and chitosan (Ch), gelatin (Gl), and alginate (Al) biopolymers were added into suspension with different ratios (100%, 75–25%, 50–50%, 25–75%). Aerogels were produced using a simple freezing and lyophilization procedure, and their suitability for use in wound dressings and other biomedical applications was evaluated. In addition to micro and morphological images, water-PBS (phosphate buffered saline) absorption rates, water vapor permeability (WVP), antibacterial efficacy, and biocompatibility tests were undertaken to study these particular features. The acquired results showed that CNF1-Gl and CNF2-Al based samples had the highest water absorption values (WAV); however, PBS results had the highest values for CNF1-Al 50–50% and CNF2-Al 75–25%, respectively. WVP data were aligned as lines from the highest to lowest degree in CNF1, CNF2, Al, Ch, and Gl. CNF1-Al showed the highest level of WVP data of 4191 g/m2 day. A microbiological study revealed that CNF/Ch and CNF/Gl bioaerogels had a greater antibacterial impact on both bacterial strains, S. aureus and E. coli. In contrast, CNF-Al based aerogels showed no antibacterial activity against either strain. The most obvious outcome is that all aerogels are biocompatible, allowing cell development on the material surface. As a result, these aerogels could be used as wound dressings in a variety of biomaterial applications.